| Pair Name | Luteolin, SMC3 | ||
| Phytochemical Name | Luteolin (PubChem CID: 5280445 ) | ||
| Anticancer drug Name | SMC3 (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Luteolin, SMC3 | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL-xL | hsa598 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Down-regulation | Activity | NFKB1 | hsa4790 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Expression | SOD2 | hsa6648 | |
| In Vitro Model | NCI-H23 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1547 |
| Result | The results suggest that combination of SMC3 and luteolin is an effective approach for improving the anticancer value of SMC3, which has implications in cancer prevention and therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells. J Cell Biochem. 2009 Dec 1;108(5):1125-31. doi: 10.1002/jcb.22346. | Click |
